The purpose of this research is to study 2 crucial biomolecules that affect the processes of ageing and cellular rejuvenation, and how they interact with other molecules. Specifically, 
we study Sirt6, an enzyme that regulates the epigenome, and the transcription factor Oct4, the pioneer factor of the induced pluripotent stem cell line. Using computational biology and computational chemistry techniques, we aim to map the interactome of the two proteins at the structural level and to design molecules that enhance their function and subsequently possess a anti-ageing or rejuvenation effect.
All in all, the knowledge derived by this study may create new insights around the information theory of ageing and support the efforts around improving protocols of reprogramming differentiated cells to induced pluripotent stem cells.
Project Τitle: COMPUTATIONAL METHODS FOR THE STUDY OF CELLULAR DEDIFFERENTIATION AND EPIGENETIC MECHANISMS IN AGEING
Project Duration: 3 years
Project URL:
Project Framework & Funding: phd student scholarships, HFRI, 32400€
Scientific coordinator (UNIWA): Minos Matsoukas
